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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis Patients
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, September 2017
|
| DOI | 10.3389/fcimb.2017.00418 |
| Pubmed ID | |
| Authors |
Stephanie A. Fong, Amanda Drilling, Sandra Morales, Marjolein E. Cornet, Bradford A. Woodworth, Wytske J. Fokkens, Alkis J. Psaltis, Sarah Vreugde, Peter-John Wormald |
| Abstract |
Introduction:Pseudomonas aeruginosa infections are prevalent amongst chronic rhinosinusitis (CRS) sufferers. Many P. aeruginosa strains form biofilms, leading to treatment failure. Lytic bacteriophages (phages) are viruses that infect, replicate within, and lyse bacteria, causing bacterial death. Aim: To assess the activity of a phage cocktail in eradicating biofilms of ex vivo P.aeruginosa isolates from CRS patients. Methods: P. aeruginosa isolates from CRS patients with and without cystic fibrosis (CF) across three continents were multi-locus sequence typed and tested for antibiotic resistance. Biofilms grown in vitro were treated with a cocktail of four phages (CT-PA). Biofilm biomass was measured after 24 and 48 h, using a crystal violet assay. Phage titrations were performed to confirm replication of the phages. A linear mixed effects model was applied to assess the effects of treatment, time, CF status, and multidrug resistance on the biomass of the biofilm. Results: The isolates included 44 strain types. CT-PA treatment significantly reduced biofilm biomass at both 24 and 48 h post-treatment (p < 0.0001), regardless of CF status or antibiotic resistance. Biomass was decreased by a median of 76% at 48 h. Decrease in biofilm was accompanied by a rise in phage titres for all except one strain. Conclusion: A single dose of phages is able to significantly reduce biofilms formed in vitro by a range of P.aeruginosa isolates from CRS patients. This represents an exciting potential and novel targeted treatment for P. aeruginosa biofilm infections and multidrug resistant bacteria. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 25% |
| Australia | 2 | 8% |
| Spain | 1 | 4% |
| Netherlands | 1 | 4% |
| United Kingdom | 1 | 4% |
| Germany | 1 | 4% |
| Venezuela, Bolivarian Republic of | 1 | 4% |
| Switzerland | 1 | 4% |
| Belgium | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 9 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 13 | 54% |
| Members of the public | 11 | 46% |
Mendeley readers
The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 236 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 18% |
| Student > Master | 40 | 17% |
| Student > Bachelor | 33 | 14% |
| Researcher | 23 | 10% |
| Student > Doctoral Student | 13 | 6% |
| Other | 25 | 11% |
| Unknown | 60 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 42 | 18% |
| Immunology and Microbiology | 41 | 17% |
| Medicine and Dentistry | 32 | 14% |
| Agricultural and Biological Sciences | 20 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Other | 24 | 10% |
| Unknown | 68 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2021.
All research outputs
#2,108,041
of 24,167,226 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#343
of 7,299 outputs
Outputs of similar age
#40,924
of 322,133 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#5
of 104 outputs
Altmetric has tracked 24,167,226 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,299 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,133 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.