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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Galectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infection
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, November 2017
|
| DOI | 10.3389/fcimb.2017.00463 |
| Pubmed ID | |
| Authors |
Aline A. da Silva, Thaise L. Teixeira, Samuel C. Teixeira, Fabrício C. Machado, Marlus A. dos Santos, Tatiana C. Tomiosso, Paula C. B. Tavares, Rebecca T. e Silva Brígido, Flávia Alves Martins, Nadjania S. de Lira Silva, Cassiano C. Rodrigues, Maria C. Roque-Barreira, Renato A. Mortara, Daiana S. Lopes, Veridiana de Melo Rodrigues Ávila, Claudio V. da Silva |
| Abstract |
Trypanosoma cruzi interacts with host cells, including cardiomyocytes, and induces the production of cytokines, chemokines, metalloproteinases, and glycan-binding proteins. Among the glycan-binding proteins is Galectin-3 (Gal-3), which is upregulated after T. cruzi infection. Gal-3 is a member of the lectin family with affinity for β-galactose containing molecules; it can be found in both the nucleus and the cytoplasm and can be either membrane-associated or secreted. This lectin is involved in several immunoregulatory and parasite infection process. Here, we explored the consequences of Gal-3 deficiency during acute and chronic T. cruzi experimental infection. Our results demonstrated that lack of Gal-3 enhanced in vitro replication of intracellular parasites, increased in vivo systemic parasitaemia, and reduced leukocyte recruitment. Moreover, we observed decreased secretion of pro-inflammatory cytokines in spleen and heart of infected Gal-3 knockout mice. Lack of Gal-3 also led to elevated mast cell recruitment and fibrosis of heart tissue. In conclusion, galectin-3 expression plays a pivotal role in controlling T. cruzi infection, preventing heart damage and fibrosis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 18% |
| Professor > Associate Professor | 3 | 8% |
| Student > Master | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Professor | 2 | 5% |
| Other | 7 | 18% |
| Unknown | 14 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 10 | 26% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Agricultural and Biological Sciences | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Decision Sciences | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 13 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2017.
All research outputs
#15,177,417
of 23,342,232 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#3,375
of 6,714 outputs
Outputs of similar age
#196,020
of 329,971 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#62
of 108 outputs
Altmetric has tracked 23,342,232 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,714 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,971 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.