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Protective Capacity of Statins during Pneumonia Is Dependent on Etiological Agent and Obesity

Overview of attention for article published in Frontiers in Cellular and Infection Microbiology, February 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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1 blog
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20 Mendeley
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Title
Protective Capacity of Statins during Pneumonia Is Dependent on Etiological Agent and Obesity
Published in
Frontiers in Cellular and Infection Microbiology, February 2018
DOI 10.3389/fcimb.2018.00041
Pubmed ID
Authors

Erik A. Karlsson, Stacey Schultz-Cherry, Jason W. Rosch

Abstract

Acute respiratory infections are a leading cause of death worldwide. Clinical data is conflicted regarding whether statins improve outcomes for pneumonia. Potential confounding factors including specific etiology of pneumonia as well as obesity could potentially mask protective benefit. Obesity is a risk factor for high cholesterol, the main target for statin therapy. We demonstrate that statin intervention conferred no protective benefit in the context of wild-type mice regardless of infectious agent. Statin intervention conferred either a protective benefit, during influenza infection, or detrimental effect, in the case of pneumococcal infection, in obese animals. These data suggest etiology of pneumonia in the context of obesity could be dramatically altered by the protective effects of statin therapy during bacterial and viral pneumonia.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 20%
Student > Bachelor 3 15%
Researcher 3 15%
Student > Master 2 10%
Lecturer > Senior Lecturer 1 5%
Other 3 15%
Unknown 4 20%
Readers by discipline Count As %
Medicine and Dentistry 6 30%
Nursing and Health Professions 2 10%
Mathematics 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Veterinary Science and Veterinary Medicine 1 5%
Other 4 20%
Unknown 5 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2018.
All research outputs
#3,747,174
of 23,023,224 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#737
of 6,510 outputs
Outputs of similar age
#92,614
of 474,288 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#22
of 131 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,510 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 474,288 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.