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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, February 2018
|
| DOI | 10.3389/fcimb.2018.00045 |
| Pubmed ID | |
| Authors |
Haritha Adhikarla, Elsio A. Wunder, Ariel E. Mechaly, Sameet Mehta, Zheng Wang, Luciane Santos, Vimla Bisht, Peter Diggle, Gerald Murray, Ben Adler, Francesc Lopez, Jeffrey P. Townsend, Eduardo Groisman, Mathieu Picardeau, Alejandro Buschiazzo, Albert I. Ko |
| Abstract |
Leptospirosis is an emerging zoonotic disease with more than 1 million cases annually. Currently there is lack of evidence for signaling pathways involved during the infection process ofLeptospira. In our comprehensive genomic analysis of 20Leptospiraspp. we identified seven pathogen-specific Two-Component System (TCS) proteins. Disruption of two these TCS genes in pathogenicLeptospirastrain resulted in loss-of-virulence in a hamster model of leptospirosis. Corresponding geneslvrAandlvrB (leptospira virulence regulator) are juxtaposed in an operon and are predicted to encode a hybrid histidine kinase and a hybrid response regulator, respectively. Transcriptome analysis oflvrmutant strains with disruption of one (lvrB) or both genes (lvrA/B) revealed global transcriptional regulation of 850 differentially expressed genes. Phosphotransfer assays demonstrated that LvrA phosphorylates LvrB and predicted further signaling downstream to one or more DNA-binding response regulators, suggesting that it is a branched pathway. Phylogenetic analyses indicated thatlvrAandlvrBevolved independently within different ecological lineages inLeptospiravia gene duplication. This study uncovers a novel-signaling pathway that regulates virulence in pathogenicLeptospira(Lvr), providing a framework to understand the molecular bases of regulation in this life-threatening bacterium. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 13% |
| Japan | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 38% |
| Members of the public | 3 | 38% |
| Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 20% |
| Researcher | 7 | 13% |
| Student > Bachelor | 6 | 11% |
| Student > Ph. D. Student | 5 | 9% |
| Professor > Associate Professor | 4 | 7% |
| Other | 7 | 13% |
| Unknown | 16 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 20% |
| Agricultural and Biological Sciences | 7 | 13% |
| Veterinary Science and Veterinary Medicine | 6 | 11% |
| Immunology and Microbiology | 5 | 9% |
| Nursing and Health Professions | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 19 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2018.
All research outputs
#6,968,736
of 23,302,246 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#1,415
of 6,677 outputs
Outputs of similar age
#120,330
of 331,072 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#38
of 125 outputs
Altmetric has tracked 23,302,246 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 6,677 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,072 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.