Title |
gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, March 2018
|
DOI | 10.3389/fcimb.2018.00055 |
Pubmed ID | |
Authors |
Bin Wang, Mengjiao Fu, Yanan Liu, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J. Zheng |
Abstract |
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). MicroRNAs (miRNAs) are involved in host-pathogen interactions and innate immune response to viral infection. However, the role of miRNAs in host response to IBDV infection is not clear. We report here that gga-miR-155 acts as an anti-virus host factor inhibiting IBDV replication. We found that transfection of DF-1 cells with gga-miR-155 suppressed IBDV replication, while blockage of the endogenous gga-miR-155 by inhibitors enhanced IBDV replication. Furthermore, our data showed that gga-miR-155 enhanced the expression of type I interferon in DF-1 cells post IBDV infection. Importantly, we found that gga-miR-155 enhanced type I interferon expression via targeting SOCS1 and TANK, two negative regulators of type I IFN signaling. These results indicate that gga-miR-155 plays a critical role in cell response to IBDV infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 21% |
Student > Ph. D. Student | 3 | 16% |
Student > Master | 2 | 11% |
Student > Doctoral Student | 1 | 5% |
Lecturer | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 32% |
Immunology and Microbiology | 3 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Chemistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 7 | 37% |