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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Emergence of Leptin in Infection and Immunity: Scope and Challenges in Vaccines Formulation
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, May 2018
|
| DOI | 10.3389/fcimb.2018.00147 |
| Pubmed ID | |
| Authors |
Dayakar Alti, Chandrasekaran Sambamurthy, Suresh K. Kalangi |
| Abstract |
Deficiency of leptin (ob/ob) and/or desensitization of leptin signaling (db/db) and elevated expression of suppressor of cytokine signaling-3 (SOCS3) reported in obesity are also reported in a variety of pathologies including hypertriglyceridemia, insulin resistance, and malnutrition as the risk factors in host defense system. Viral infections cause the elevated SOCS3 expression, which inhibits leptin signaling. It results in immunosuppression by T-regulatory cells (Tregs). The host immunity becomes incompetent to manage pathogens' attack and invasion, which results in the accelerated infections and diminished vaccine-specific antibody response. Leptin was successfully used as mucosal vaccine adjuvant against Rhodococcus equi. Leptin induced the antibody response to Helicobacter pylori vaccination in mice. An integral leptin signaling in mucosal gut epithelial cells offered resistance against Clostridium difficile and Entameoba histolytica infections. We present in this review, the intervention of leptin in lethal diseases caused by microbial infections and propose the possible scope and challenges of leptin as an adjuvant tool in the development of effective vaccines. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ecuador | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 14% |
| Student > Bachelor | 10 | 13% |
| Researcher | 9 | 11% |
| Student > Master | 8 | 10% |
| Lecturer | 5 | 6% |
| Other | 17 | 21% |
| Unknown | 20 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 13 | 16% |
| Medicine and Dentistry | 12 | 15% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Agricultural and Biological Sciences | 6 | 8% |
| Nursing and Health Professions | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 29 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2022.
All research outputs
#14,427,926
of 23,577,654 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#2,609
of 6,873 outputs
Outputs of similar age
#180,753
of 328,661 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#50
of 112 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,873 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,661 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.