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Mendeley readers
Attention Score in Context
| Title |
Genomic Comparison Among Global Isolates of L. interrogans Serovars Copenhageni and Icterohaemorrhagiae Identified Natural Genetic Variation Caused by an Indel
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, June 2018
|
| DOI | 10.3389/fcimb.2018.00193 |
| Pubmed ID | |
| Authors |
Luciane A. Santos, Haritha Adhikarla, Xiting Yan, Zheng Wang, Derrick E. Fouts, Joseph M. Vinetz, Luiz C. J. Alcantara, Rudy A. Hartskeerl, Marga G. A. Goris, Mathieu Picardeau, Mitermayer G. Reis, Jeffrey P. Townsend, Hongyu Zhao, Albert I. Ko, Elsio A. Wunder |
| Abstract |
Leptospirosis is a worldwide zoonosis, responsible for more than 1 million cases and 60,000 deaths every year. Among the 13 pathogenic species of the genus Leptospira, serovars belonging to L. interrogans serogroup Icterohaemorrhagiae are considered to be the most virulent strains, and responsible for majority of the reported severe cases. Serovars Copenhageni and Icterohaemorrhagiae are major representatives of this serogroup and despite their public health relevance, little is known regarding the genetic differences between these two serovars. In this study, we analyzed the genome sequences of 67 isolates belonging to L. interrogans serovars Copenhageni and Icterohaemorrhagiae to investigate the influence of spatial and temporal variations on DNA sequence diversity. Out of the 1072 SNPs identified, 276 were in non-coding regions and 796 in coding regions. Indel analyses identified 258 indels, out of which 191 were found in coding regions and 67 in non-coding regions. Our phylogenetic analyses based on SNP dataset revealed that both serovars are closely related but showed distinct spatial clustering. However, likelihood ratio test of the indel data statistically confirmed the presence of a frameshift mutation within a homopolymeric tract of lic12008 gene (related to LPS biosynthesis) in all the L. interrogans serovar Icterohaemorrhagiae strains but not in the Copenhageni strains. Therefore, this internal indel identified can genetically distinguish L. interrogans serovar Copenhageni from serovar Icterohaemorrhagiae with high discriminatory power. To our knowledge, this is the first study to identify global sequence variations (SNPs and Indels) in L. interrogans serovars Copenhageni and Icterohaemorrhagiae. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 16% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 6 | 9% |
| Student > Ph. D. Student | 5 | 7% |
| Other | 11 | 16% |
| Unknown | 21 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 14% |
| Veterinary Science and Veterinary Medicine | 9 | 13% |
| Immunology and Microbiology | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Medicine and Dentistry | 4 | 6% |
| Other | 13 | 19% |
| Unknown | 22 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2018.
All research outputs
#18,639,173
of 23,090,520 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#4,955
of 6,557 outputs
Outputs of similar age
#252,990
of 328,030 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#104
of 121 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,557 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,030 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.