Title |
All Yersinia Are Not Created Equal: Phenotypic Adaptation to Distinct Niches Within Mammalian Tissues
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, August 2018
|
DOI | 10.3389/fcimb.2018.00261 |
Pubmed ID | |
Authors |
Kimberly M. Davis |
Abstract |
Yersinia pseudotuberculosis replicates within mammalian tissues to form clustered bacterial replication centers, called microcolonies. A subset of bacterial cells within microcolonies interact directly with host immune cells, and other subsets of bacteria only interact with other bacteria. This establishes a system where subsets of Yersinia have distinct gene expression profiles, which are driven by their unique microenvironments and cellular interactions. When this leads to alterations in virulence gene expression, small subsets of bacteria can play a critical role in supporting the replication of the bacterial population, and can drive the overall disease outcome. Based on the pathology of infections with each of the three Yersinia species that are pathogenic to humans, it is likely that this specialization of bacterial subsets occurs during all Yersiniae infections. This review will describe the pathology that occurs during infection with each of the three human pathogenic Yersinia, in terms of the structure of bacterial replication centers and the specific immune cell subsets that bacteria interact with, and will also describe the outcome these interactions have or may have on bacterial gene expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 56% |
United Kingdom | 2 | 11% |
China | 1 | 6% |
Germany | 1 | 6% |
Chile | 1 | 6% |
Switzerland | 1 | 6% |
Unknown | 2 | 11% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 10 | 56% |
Practitioners (doctors, other healthcare professionals) | 4 | 22% |
Members of the public | 4 | 22% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 22% |
Student > Master | 7 | 19% |
Student > Bachelor | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Student > Doctoral Student | 2 | 6% |
Other | 3 | 8% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 14 | 39% |
Biochemistry, Genetics and Molecular Biology | 6 | 17% |
Medicine and Dentistry | 3 | 8% |
Agricultural and Biological Sciences | 3 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 2 | 6% |
Unknown | 7 | 19% |