Title |
The Abdominal Aortic Aneurysm and Intraluminal Thrombus: Current Concepts of Development and Treatment
|
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Published in |
Frontiers in Cardiovascular Medicine, May 2015
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DOI | 10.3389/fcvm.2015.00019 |
Pubmed ID | |
Authors |
Aleksandra Piechota-Polanczyk, Alicja Jozkowicz, Witold Nowak, Wolf Eilenberg, Christoph Neumayer, Tadeusz Malinski, Ihor Huk, Christine Brostjan |
Abstract |
The pathogenesis of the abdominal aortic aneurysm (AAA) shows several hallmarks of atherosclerotic and atherothrombotic disease, but comprises an additional, predominant feature of proteolysis resulting in the degradation and destabilization of the aortic wall. This review aims to summarize the current knowledge on AAA development, involving the accumulation of neutrophils in the intraluminal thrombus and their central role in creating an oxidative and proteolytic environment. Particular focus is placed on the controversial role of heme oxygenase 1/carbon monoxide and nitric oxide synthase/peroxynitrite, which may exert both protective and damaging effects in the development of the aneurysm. Treatment indications as well as surgical and pharmacological options for AAA therapy are discussed in light of recent reports. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Austria | 1 | <1% |
Unknown | 122 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 11% |
Student > Doctoral Student | 14 | 11% |
Student > Bachelor | 14 | 11% |
Student > Master | 12 | 10% |
Other | 11 | 9% |
Other | 27 | 22% |
Unknown | 31 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 40% |
Engineering | 13 | 11% |
Agricultural and Biological Sciences | 7 | 6% |
Biochemistry, Genetics and Molecular Biology | 6 | 5% |
Nursing and Health Professions | 2 | 2% |
Other | 4 | 3% |
Unknown | 42 | 34% |