Title |
Radiation-Induced Cardiovascular Disease: A Clinical Perspective
|
---|---|
Published in |
Frontiers in Cardiovascular Medicine, October 2017
|
DOI | 10.3389/fcvm.2017.00066 |
Pubmed ID | |
Authors |
Syed Wamique Yusuf, Bhanu Prasad Venkatesulu, Lakshmi Shree Mahadevan, Sunil Krishnan |
Abstract |
Cancer survival has improved dramatically, and this has led to the manifestation of late side effects of multimodality therapy. Radiation (RT) to the thoracic malignancies results in unintentional irradiation of the cardiac chambers. RT-induced microvascular ischemia leads to disruption of capillary endothelial framework, and injury to differentiated myocytes results in deposition of collagen and fibrosis. Coexistence of risk factors of metabolic syndrome and preexisting atherosclerosis in addition to RT exposure results in accelerated occurrence of major coronary events. Hence, it becomes pertinent to understand the underlying pathophysiology and clinical manifestations of RT-induced cardiovascular disease to devise optimal preventive and surveillance strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 10 | 15% |
Researcher | 10 | 15% |
Student > Ph. D. Student | 8 | 12% |
Student > Bachelor | 5 | 7% |
Student > Master | 5 | 7% |
Other | 8 | 12% |
Unknown | 22 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 37% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Agricultural and Biological Sciences | 2 | 3% |
Other | 5 | 7% |
Unknown | 27 | 40% |