Title |
Low Affinity GPCRs for Metabolic Intermediates: Challenges for Pharmacologists
|
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Published in |
Frontiers in endocrinology, January 2012
|
DOI | 10.3389/fendo.2012.00001 |
Pubmed ID | |
Authors |
Nicola J. Smith |
Abstract |
The discovery that a number of metabolites and metabolic intermediates can act through G protein-coupled receptors has attracted great interest in the field and has led to new therapeutic targets for diseases such as hypertension, type 2 diabetes, inflammation, and metabolic syndrome. However, the low apparent affinity of these ligands for their cognate receptors poses a number of challenges for pharmacologists interested in investigating receptor structure, function or physiology. Furthermore, the endogenous ligands matched to their receptors have other, well established metabolic roles and thus selectivity is difficult to achieve. This review discusses some of the issues researchers face when working with these receptors and highlights the ways in which a number of these obstacles have been overcome. |
X Demographics
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 5% |
Denmark | 1 | 5% |
Unknown | 20 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 27% |
Student > Doctoral Student | 4 | 18% |
Student > Ph. D. Student | 3 | 14% |
Student > Bachelor | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Other | 3 | 14% |
Unknown | 2 | 9% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 18% |
Biochemistry, Genetics and Molecular Biology | 4 | 18% |
Medicine and Dentistry | 3 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Environmental Science | 1 | 5% |
Other | 6 | 27% |
Unknown | 2 | 9% |