Title |
Colonic flora, Probiotics, Obesity and Diabetes
|
---|---|
Published in |
Frontiers in endocrinology, January 2012
|
DOI | 10.3389/fendo.2012.00087 |
Pubmed ID | |
Authors |
Paul E. Marik |
Abstract |
Obesity results from alterations in the body's regulation of energy intake, expenditure, and storage. Animal and human data demonstrate that phylogenic changes occur in the microbiota composition in obese individuals. Furthermore, evidence from animal models suggest that the alterations of the gut microbiota with obesity results in increased energy extraction and lipid deposition, altered release of entero-hormones, increased intestinal permeability and metabolic endotoxemia. Treatment with pre- and probiotics may reverse many of metabolic effects linked with the altered microbiota in obese patients. The gut microbiota is, therefore, a potential nutritional and pharmacological target for the management of obesity and obesity-related disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
Netherlands | 1 | 13% |
Australia | 1 | 13% |
Canada | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Practitioners (doctors, other healthcare professionals) | 3 | 38% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 113 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 32 | 28% |
Student > Bachelor | 19 | 17% |
Other | 13 | 11% |
Researcher | 11 | 10% |
Student > Ph. D. Student | 8 | 7% |
Other | 20 | 17% |
Unknown | 12 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 38 | 33% |
Agricultural and Biological Sciences | 30 | 26% |
Biochemistry, Genetics and Molecular Biology | 11 | 10% |
Nursing and Health Professions | 7 | 6% |
Immunology and Microbiology | 3 | 3% |
Other | 12 | 10% |
Unknown | 14 | 12% |