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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cancer stem cells, tumor dormancy, and metastasis
|
|---|---|
| Published in |
Frontiers in endocrinology, January 2012
|
| DOI | 10.3389/fendo.2012.00125 |
| Pubmed ID | |
| Authors |
Purvi Patel, Emily I. Chen |
| Abstract |
Tumor cells can persist undetectably for an extended period of time in primary tumors and in disseminated cancer cells. Very little is known about why and how these tumors persist for extended periods of time and then evolve to malignancy. The discovery of cancer stem cells (CSCs) in human tumors challenges our current understanding of tumor recurrence, drug resistance, and metastasis, and opens up new research directions on how cancer cells are capable of switching from dormancy to malignancy. Although overlapping molecules and pathways have been reported to regulate the stem-like phenotype of CSCs and metastasis, accumulated evidence has suggested additional clonal diversity within the stem-like cancer cell subpopulation. This review will describe the current hypothesis linking CSCs and metastasis and summarize mechanisms important for metastatic CSCs to re-initiate tumors in the secondary sites. A better understanding of CSCs' contribution to clinical tumor dormancy and metastasis will provide new therapeutic revenues to eradicate metastatic tumors and significantly reduce the mortality of cancer patients. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 20% |
| Canada | 1 | 20% |
| Central African Republic | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 68 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 29% |
| Researcher | 14 | 20% |
| Student > Bachelor | 5 | 7% |
| Student > Master | 5 | 7% |
| Professor > Associate Professor | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 27% |
| Biochemistry, Genetics and Molecular Biology | 17 | 24% |
| Agricultural and Biological Sciences | 11 | 16% |
| Chemistry | 2 | 3% |
| Immunology and Microbiology | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 14 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2020.
All research outputs
#14,387,928
of 25,373,627 outputs
Outputs from Frontiers in endocrinology
#2,758
of 13,009 outputs
Outputs of similar age
#152,284
of 250,087 outputs
Outputs of similar age from Frontiers in endocrinology
#43
of 138 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,009 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,087 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.