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Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism?

Overview of attention for article published in Frontiers in endocrinology, January 2013
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Title
Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism?
Published in
Frontiers in endocrinology, January 2013
DOI 10.3389/fendo.2012.00176
Pubmed ID
Authors

John M. Hutson, Ruili Li, Bridget R. Southwell, Bodil L. Petersen, Jorgen Thorup, Dina Cortes

Abstract

To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 10 14%
Researcher 9 12%
Student > Master 8 11%
Student > Doctoral Student 5 7%
Professor 5 7%
Other 17 23%
Unknown 19 26%
Readers by discipline Count As %
Medicine and Dentistry 26 36%
Agricultural and Biological Sciences 8 11%
Biochemistry, Genetics and Molecular Biology 7 10%
Nursing and Health Professions 3 4%
Veterinary Science and Veterinary Medicine 3 4%
Other 3 4%
Unknown 23 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2013.
All research outputs
#22,778,604
of 25,394,764 outputs
Outputs from Frontiers in endocrinology
#8,341
of 13,033 outputs
Outputs of similar age
#258,564
of 289,149 outputs
Outputs of similar age from Frontiers in endocrinology
#132
of 210 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,033 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,149 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.