Title |
Ontogenesis of Gonadotropin-Releasing Hormone Neurons: A Model for Hypothalamic Neuroendocrine Cell Development
|
---|---|
Published in |
Frontiers in endocrinology, January 2013
|
DOI | 10.3389/fendo.2013.00089 |
Pubmed ID | |
Authors |
Erica L. Stevenson, Kristina M. Corella, Wilson C. J. Chung |
Abstract |
The vertebrate hypothalamo-pituitary-gonadal axis is the anatomical framework responsible for reproductive competence and species propagation. Essential to the coordinated actions of this three-tiered biological system is the fact that the regulatory inputs ultimately converge on the gonadotropin-releasing hormone (GnRH) neuronal system, which in rodents primarily resides in the preoptic/hypothalamic region. In this short review we will focus on: (1) the general embryonic temporal and spatial development of the rodent GnRH neuronal system, (2) the origin(s) of GnRH neurons, and (3) which transcription - and growth factors have been found to be critical for GnRH neuronal ontogenesis and cellular fate-specification. Moreover, we ask the question whether the molecular and cellular mechanisms involved in GnRH neuronal development may also play a role in the development of other hypophyseal secreting neuroendocrine cells in the hypothalamus. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 21% |
Student > Bachelor | 5 | 17% |
Student > Master | 5 | 17% |
Researcher | 4 | 14% |
Professor | 1 | 3% |
Other | 3 | 10% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 34% |
Biochemistry, Genetics and Molecular Biology | 9 | 31% |
Mathematics | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Neuroscience | 1 | 3% |
Other | 0 | 0% |
Unknown | 7 | 24% |