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X Demographics
Mendeley readers
Attention Score in Context
| Title |
FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases
|
|---|---|
| Published in |
Frontiers in endocrinology, July 2014
|
| DOI | 10.3389/fendo.2014.00107 |
| Pubmed ID | |
| Authors |
Nobuyuki Itoh |
| Abstract |
Fibroblast growth factor (FGF) family members are mostly secreted as signaling proteins with diverse functions in development and metabolism. FGF21 is a unique FGF with metabolic, but not proliferative activities. FGF21 is mostly induced by different kinds of stress and acts though FGF receptor 1c with β-Klotho as a cofactor in an endocrine or, in parts, autocrine/paracrine manner. Hepatic FGF21 directly acts on white adipocytes to inhibit lipolysis and acts through the brain to increase systemic glucocorticoid levels and suppress physical activity in response to starvation. It also protects against dioxin toxicity. Adipocytic FGF21 induces the browning of white adipose tissue (WAT) and activates brown adipocytes in response to cold exposure. It also acts as an upstream effector of adiponectin in white adipocytes. Myocytic FGF21 protects against diet-induced obesity and insulin resistance, induces the browning of WAT, and protects against cardiac hypertrophy. In addition, Fgf21 polymorphisms are possibly related with metabolic diseases and FGF21 are biomarker of metabolic diseases. These findings indicate that FGF21 plays roles as a hepatokine, adipokine, and myokine in metabolism, injury protection, and diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Mexico | 2 | 1% |
| Italy | 1 | <1% |
| Chile | 1 | <1% |
| Iraq | 1 | <1% |
| Unknown | 173 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 23% |
| Student > Bachelor | 21 | 12% |
| Student > Master | 19 | 10% |
| Researcher | 18 | 10% |
| Student > Doctoral Student | 14 | 8% |
| Other | 31 | 17% |
| Unknown | 37 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 40 | 22% |
| Medicine and Dentistry | 34 | 19% |
| Biochemistry, Genetics and Molecular Biology | 32 | 18% |
| Sports and Recreations | 8 | 4% |
| Nursing and Health Professions | 4 | 2% |
| Other | 20 | 11% |
| Unknown | 43 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2014.
All research outputs
#15,169,949
of 25,374,647 outputs
Outputs from Frontiers in endocrinology
#3,365
of 13,012 outputs
Outputs of similar age
#121,000
of 240,377 outputs
Outputs of similar age from Frontiers in endocrinology
#20
of 53 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,012 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,377 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.