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Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes

Overview of attention for article published in Frontiers in endocrinology, October 2014
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Title
Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes
Published in
Frontiers in endocrinology, October 2014
DOI 10.3389/fendo.2014.00186
Pubmed ID
Authors

Jonas Sieber, Andreas Werner Jehle

Abstract

Podocyte injury and loss critically contribute to the pathogenesis of proteinuric kidney diseases including diabetic nephropathy. Deregulated lipid metabolism with disturbed free fatty acid (FFA) metabolism is a characteristic of metabolically unhealthy obesity and type 2 diabetes and likely contributes to end-stage kidney disease irrespective of the underlying kidney disease. In the current review, we summarize recent findings related to FFAs and altered renal FFA metabolism with a special focus on podocytes. We will outline the opposing effects of saturated and monounsaturated FFAs and a particular emphasis will be given to the underlying molecular mechanisms involving insulin resistance and endoplasmic reticulum homeostasis. Finally, recent data suggesting a critical role of renal FFA metabolism to adapt to an altered lipid environment will be discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 13%
Student > Bachelor 7 13%
Student > Master 7 13%
Other 5 9%
Researcher 5 9%
Other 10 18%
Unknown 14 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 24%
Biochemistry, Genetics and Molecular Biology 10 18%
Medicine and Dentistry 9 16%
Unspecified 2 4%
Nursing and Health Professions 2 4%
Other 4 7%
Unknown 15 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2014.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Frontiers in endocrinology
#5,287
of 13,012 outputs
Outputs of similar age
#164,282
of 273,628 outputs
Outputs of similar age from Frontiers in endocrinology
#29
of 62 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,012 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,628 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.