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The Podocyte Power-Plant Disaster and Its Contribution to Glomerulopathy

Overview of attention for article published in Frontiers in endocrinology, December 2014
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Title
The Podocyte Power-Plant Disaster and Its Contribution to Glomerulopathy
Published in
Frontiers in endocrinology, December 2014
DOI 10.3389/fendo.2014.00209
Pubmed ID
Authors

Janina Müller-Deile, Mario Schiffer

Abstract

Proper podocyte function within the glomerulus demands a high and continuous energy supply that is mainly derived from the respiratory chain of the inner mitochondrial membrane. Dysregulations in the metabolic homeostasis of podocytes may result in podocyte damage and glomerular disease. This article highlights the current knowledge about podocyte energy supply by the respiratory chain. We review the regulation of mitochondrial oxidative metabolism with regard to podocytopathy and discuss the latest understanding of different mitochondrial dysfunctions of the podocyte in diabetic nephropathy and focal segmental glomerulosclerosis (FSGS). We discuss genetic forms of mitochondriopathy of the podocyte and end with recent knowledge about crosstalk between NADH and NADPH and potential therapeutic options for podocyte mitochondriopathy. We aim to raise awareness for the complex and interesting mechanisms of podocyte damage by impaired energy supply that, despite of novel findings in recent years, is poorly understood so far.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 26%
Student > Master 6 18%
Student > Ph. D. Student 5 15%
Other 3 9%
Student > Postgraduate 2 6%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 8 24%
Agricultural and Biological Sciences 7 21%
Biochemistry, Genetics and Molecular Biology 5 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 12%
Computer Science 2 6%
Other 1 3%
Unknown 7 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2015.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from Frontiers in endocrinology
#5,754
of 13,012 outputs
Outputs of similar age
#253,644
of 360,879 outputs
Outputs of similar age from Frontiers in endocrinology
#27
of 59 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,012 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,879 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.