Title |
New Directions for the Treatment of Adrenal Insufficiency
|
---|---|
Published in |
Frontiers in endocrinology, May 2015
|
DOI | 10.3389/fendo.2015.00070 |
Pubmed ID | |
Authors |
Gerard Ruiz-Babot, Irene Hadjidemetriou, Peter James King, Leonardo Guasti |
Abstract |
Adrenal disease, whether primary, caused by defects in the hypothalamic-pituitary-adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of corticosteroids. However, this kind of therapy is far from ideal as physiological demand for steroids varies considerably throughout the day and increases during periods of stress. The development of alternative curative strategies is therefore needed. In this review, we describe the latest technologies aimed at either isolating or generating de novo cells that could be used for novel, regenerative medicine application in the adrenocortical field. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 23% |
Student > Bachelor | 10 | 17% |
Student > Ph. D. Student | 7 | 12% |
Student > Postgraduate | 6 | 10% |
Student > Master | 6 | 10% |
Other | 10 | 17% |
Unknown | 7 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 42% |
Biochemistry, Genetics and Molecular Biology | 14 | 23% |
Agricultural and Biological Sciences | 6 | 10% |
Chemistry | 2 | 3% |
Nursing and Health Professions | 1 | 2% |
Other | 4 | 7% |
Unknown | 8 | 13% |