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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link
|
|---|---|
| Published in |
Frontiers in endocrinology, May 2015
|
| DOI | 10.3389/fendo.2015.00077 |
| Pubmed ID | |
| Authors |
Laura W. Bowers, Emily L. Rossi, Ciara H. O’Flanagan, Linda A. deGraffenried, Stephen D. Hursting |
| Abstract |
Numerous epidemiological and pre-clinical studies have demonstrated that the insulin/insulin-like growth factor (IGF) system plays a key role in the development and progression of several types of cancer. Insulin/IGF signaling, in cooperation with chronic low-grade inflammation, is also an important contributor to the cancer-promoting effects of obesity. However, clinical trials for drugs targeting different components of this system have produced largely disappointing results, possibly due to the lack of predictive biomarker use and problems with the design of combination therapy regimens. With careful attention to the identification of likely patient responders and optimal drug combinations, the outcome of future trials may be improved. Given that insulin/IGF signaling is known to contribute to obesity-associated cancer, further investigation regarding the efficacy of drugs targeting this system and its downstream effectors in the obese patient population is warranted. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 135 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 17% |
| Student > Master | 23 | 17% |
| Researcher | 15 | 11% |
| Student > Postgraduate | 14 | 10% |
| Student > Bachelor | 13 | 9% |
| Other | 24 | 18% |
| Unknown | 25 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 29% |
| Biochemistry, Genetics and Molecular Biology | 27 | 20% |
| Nursing and Health Professions | 15 | 11% |
| Agricultural and Biological Sciences | 12 | 9% |
| Neuroscience | 4 | 3% |
| Other | 10 | 7% |
| Unknown | 29 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2023.
All research outputs
#2,007,336
of 25,628,260 outputs
Outputs from Frontiers in endocrinology
#520
of 13,257 outputs
Outputs of similar age
#24,850
of 279,946 outputs
Outputs of similar age from Frontiers in endocrinology
#5
of 53 outputs
Altmetric has tracked 25,628,260 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,257 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,946 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.