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Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia

Overview of attention for article published in Frontiers in endocrinology, June 2015
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Title
Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia
Published in
Frontiers in endocrinology, June 2015
DOI 10.3389/fendo.2015.00087
Pubmed ID
Authors

Enaam T. Elhaj, Ishag Adam, Ammar Alim, Elhassan M. Elhassan, Mohamed F. Lutfi

Abstract

Preeclampsia is an important cause of maternal and prenatal morbidity and mortality in the developing countries. Changes in thyroid function/antibodies profiles in preeclamptic women are controversial and were never investigated before in Sudan. A case-control study was conducted at Medani Hospital, Sudan, to investigate thyroid function/antibodies in preeclampsia. The sociodemographic, medical history was gathered using questionnaires. Thyroid hormones [thyroid-stimulating hormone (TSH), free tri-iodothyronine (T3), and free thyroxine (T4)] and anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies were measured using ELISA. The three groups [controls, mild, and severe preeclampsia (SP) (55 women in each arm)] were matched in age and parity. While median (interquartile range) of TSH was significantly lower, both free T3 and free T4 levels were significantly higher in women with preeclampsia than in the healthy controls. There was no significant difference in the TSH levels in women with MP and SP. In comparison with women with MP, women with SP had significantly higher levels of free T3 and significantly lower levels of free T4. While anti-TPO antibodies were significantly higher, anti-TG antibodies were significantly lower in women with preeclampsia. Likewise, anti-TPO antibodies were significantly higher and anti-TG antibodies were significantly lower in women with SP than in women with MP. In linear regression, preeclampsia was significantly associated with TSH (-0.675 IU/ml, P = 0.009), free T3 (0.977 pg/ml, P < 0.001), and free T4 (0.186 ng/dl, P < 0.001) levels. In contrast to anti-TG antibodies and TSH, Sudanese patients with preeclampsia had higher levels of T3 and T4 hormones and anti-TPO antibodies irrespective of parity, gestational age, and hemoglobin levels.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 4 17%
Professor 3 13%
Student > Doctoral Student 2 9%
Other 2 9%
Student > Master 2 9%
Other 6 26%
Unknown 4 17%
Readers by discipline Count As %
Medicine and Dentistry 12 52%
Biochemistry, Genetics and Molecular Biology 3 13%
Chemistry 1 4%
Agricultural and Biological Sciences 1 4%
Unknown 6 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2015.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Frontiers in endocrinology
#6,734
of 13,012 outputs
Outputs of similar age
#206,130
of 280,836 outputs
Outputs of similar age from Frontiers in endocrinology
#37
of 56 outputs
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