Title |
Metabolic Effects of FGF-21: Thermoregulation and Beyond
|
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Published in |
Frontiers in endocrinology, September 2015
|
DOI | 10.3389/fendo.2015.00148 |
Pubmed ID | |
Authors |
Bin Ni, Jared S. Farrar, Janina A. Vaitkus, Francesco S. Celi |
Abstract |
Fibroblast growth factor (FGF)-21, a member of the FGF family, is a novel hormone involved in the control of metabolism by modulating glucose homeostasis, insulin sensitivity, ketogenesis, and promoting adipose tissue "browning." Recent studies demonstrated that brown adipose tissue is not only a target for FGF-21, but is also a potentially important source of systemic FGF-21. These findings support the hypothesis that FGF-21 plays a physiologic role in thermogenesis and thermogenic recruitment of white adipose tissue by an autocrine-paracrine axis. This review examines the role of FGF-21 in thermogenesis from the perspective of cell-based, animal model, and human studies. We also present recent advances in the characterization of FGF-21's regulation of metabolism. |
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