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Comparative Effect of ACTH and Related Peptides on Proliferation and Growth of Rat Adrenal Gland

Overview of attention for article published in Frontiers in endocrinology, May 2016
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  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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Title
Comparative Effect of ACTH and Related Peptides on Proliferation and Growth of Rat Adrenal Gland
Published in
Frontiers in endocrinology, May 2016
DOI 10.3389/fendo.2016.00039
Pubmed ID
Authors

Claudimara Ferini Pacicco Lotfi, Pedro O. R. de Mendonca

Abstract

Pro-opiomelanocortin (POMC) is a polypeptide precursor known to yield biologically active peptides related to a range of functions. These active peptides include the adrenocorticotropic hormone (ACTH), which is essential for maintenance of adrenal growth and steroidogenesis, and the alpha-melanocyte stimulation hormone, which plays a key role in energy homeostasis. However, the role of the highly conserved N-terminal region of POMC peptide fragments has begun to be unraveled only recently. Here, we review the cascade of events involved in regulation of proliferation and growth of murine adrenal cortex triggered by ACTH and other POMC-derived peptides. Key findings regarding signaling pathways and modulation of genes and proteins required for the regulation of adrenal growth are summarized. We have outlined the known mechanisms as well as future challenges for research on the regulation of adrenal proliferation and growth triggered by these peptides.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 28%
Student > Doctoral Student 2 11%
Student > Master 2 11%
Other 1 6%
Student > Bachelor 1 6%
Other 2 11%
Unknown 5 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 28%
Biochemistry, Genetics and Molecular Biology 3 17%
Medicine and Dentistry 2 11%
Veterinary Science and Veterinary Medicine 1 6%
Neuroscience 1 6%
Other 0 0%
Unknown 6 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2016.
All research outputs
#16,580,157
of 25,374,647 outputs
Outputs from Frontiers in endocrinology
#4,292
of 13,012 outputs
Outputs of similar age
#182,516
of 315,804 outputs
Outputs of similar age from Frontiers in endocrinology
#21
of 48 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,012 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,804 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.