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Ultrasound-Guided Percutaneous Ethanol Injection Protocol to Treat Solid and Mixed Thyroid Nodules

Overview of attention for article published in Frontiers in endocrinology, June 2016
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Title
Ultrasound-Guided Percutaneous Ethanol Injection Protocol to Treat Solid and Mixed Thyroid Nodules
Published in
Frontiers in endocrinology, June 2016
DOI 10.3389/fendo.2016.00052
Pubmed ID
Authors

João Soares Felício, Antônio Maria Silva Conceição, Flávia Marques Santos, Michelle Masuyo Minami Sato, Fabíola de Arruda Bastos, Ana Carolina Contente Braga de Souza, Camila Cavalcante Koury, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Thaís Pontes Arbage, Antonio Bentes de Figueiredo, Hana Andrade de Rider Brito, Marcelo Oliveira Mourão Júnior, Fabricio de Souza Resende, Amanda Soares Peixoto, Karem Miléo Felício

Abstract

Ultrasound (US)-guided percutaneous ethanol injection (PEI) has been proposed for treatment of benign thyroid nodules (TNs). However, there is no consensus for the optimal amount of ethanol injection, number of applications, and time to re-evaluation in order to achieve maximum volume reduction with minimum adverse effects. The purpose of the present study was to analyze the effectiveness of an US-guided PEI protocol to treat solid and mixed TNs based on a new target outcome. We performed a prospective study evaluating the results of PEI in 52 patients with benign solid and mixed TNs. The ethanol dose was fixed in 30% of the nodular volume per session. Patients returned 1 month after each session for US re-evaluation. Therapeutic success was defined as volume reduction of at least 30% associated with disappearance of clinical symptoms and a complete esthetic satisfaction reported by the patient. We performed a mean of 2.8 ± 1.9 PEI sessions, with an average total volume of ethanol injected of 9.1 ± 10.3 ml, and a follow-up time of 10.0 ± 8.7 months. There was a reduction of at least 50% of the initial nodular volume in 33 patients (63.5%). In 11 patients (21.2%), the reduction did not reach 50% (mean reduction of 31 ± 11%), but 6 of them reported esthetically satisfactory results and treatment was stopped. Our therapeutic success rate considering the patients with esthetic improvement was 75%. There were no severe complications. Our protocol is effective and safe to treat solid and mixed benign TNs based on our established outcome.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 13%
Researcher 2 13%
Lecturer > Senior Lecturer 1 7%
Student > Ph. D. Student 1 7%
Other 1 7%
Other 2 13%
Unknown 6 40%
Readers by discipline Count As %
Medicine and Dentistry 8 53%
Agricultural and Biological Sciences 1 7%
Environmental Science 1 7%
Unknown 5 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2018.
All research outputs
#16,048,009
of 25,374,647 outputs
Outputs from Frontiers in endocrinology
#3,937
of 13,012 outputs
Outputs of similar age
#205,374
of 355,635 outputs
Outputs of similar age from Frontiers in endocrinology
#21
of 64 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,012 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,635 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.