Title |
Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers
|
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Published in |
Frontiers in endocrinology, July 2016
|
DOI | 10.3389/fendo.2016.00100 |
Pubmed ID | |
Authors |
Ryuta Tanimoto, Kuojung G. Lu, Shi-Qiong Xu, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione |
Abstract |
The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 14% |
Professor | 3 | 14% |
Student > Bachelor | 3 | 14% |
Student > Ph. D. Student | 2 | 10% |
Other | 1 | 5% |
Other | 4 | 19% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Neuroscience | 3 | 14% |
Nursing and Health Professions | 1 | 5% |
Unspecified | 1 | 5% |
Other | 2 | 10% |
Unknown | 7 | 33% |