Title |
Role of lncRNAs in Cellular Aging
|
---|---|
Published in |
Frontiers in endocrinology, December 2016
|
DOI | 10.3389/fendo.2016.00151 |
Pubmed ID | |
Authors |
Ufuk Degirmenci, Sun Lei |
Abstract |
Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 33% |
United States | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 69 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 20% |
Student > Ph. D. Student | 12 | 17% |
Student > Bachelor | 7 | 10% |
Professor > Associate Professor | 5 | 7% |
Student > Doctoral Student | 3 | 4% |
Other | 11 | 16% |
Unknown | 17 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 24 | 35% |
Agricultural and Biological Sciences | 13 | 19% |
Medicine and Dentistry | 5 | 7% |
Neuroscience | 3 | 4% |
Immunology and Microbiology | 1 | 1% |
Other | 3 | 4% |
Unknown | 20 | 29% |