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Gonadotropin-Inhibitory Hormone Plays Roles in Stress-Induced Reproductive Dysfunction

Overview of attention for article published in Frontiers in endocrinology, April 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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2 news outlets
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1 X user
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1 Facebook page

Citations

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27 Dimensions

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47 Mendeley
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Title
Gonadotropin-Inhibitory Hormone Plays Roles in Stress-Induced Reproductive Dysfunction
Published in
Frontiers in endocrinology, April 2017
DOI 10.3389/fendo.2017.00062
Pubmed ID
Authors

Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Minoru Irahara

Abstract

Physical and psychological stressors suppress hypothalamic-pituitary-gonadal axis activity and sexual behavior and consequently induce reproductive dysfunction. Recently, it has been shown that gonadotropin-inhibitory hormone (GnIH), also called RFamide-related peptide 3 (RFRP) in mammals, which is a potent inhibitory regulator of gonadotropin-releasing hormone (GnRH) and gonadotropin, is involved in stress-induced reproductive dysfunction. GnIH/Rfrp (the gene coding RFRP-3) expression and activity are increased by psychological and immune stress, and this alteration suppresses GnRH and gonadotropin secretion. Glucocorticoid acts as a mediator that interacts between stress and hypothalamic GnIH/RFRP-3. GnIH/RFRP-3 also plays important roles in stress-induced suppression of sexual behavior and infertility, and genetic silencing of GnIH/Rfrp completely recovers sexual behavior and fertility. This review summarizes what is currently known about the roles of GnIH in stress-induced reproductive dysfunction.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 19%
Student > Ph. D. Student 7 15%
Student > Postgraduate 5 11%
Researcher 4 9%
Student > Bachelor 3 6%
Other 7 15%
Unknown 12 26%
Readers by discipline Count As %
Medicine and Dentistry 10 21%
Neuroscience 5 11%
Biochemistry, Genetics and Molecular Biology 5 11%
Agricultural and Biological Sciences 3 6%
Psychology 2 4%
Other 8 17%
Unknown 14 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2023.
All research outputs
#2,148,418
of 25,382,440 outputs
Outputs from Frontiers in endocrinology
#555
of 13,018 outputs
Outputs of similar age
#39,957
of 324,569 outputs
Outputs of similar age from Frontiers in endocrinology
#2
of 72 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,018 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,569 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.