Title |
Gonadotropin-Inhibitory Hormone Plays Roles in Stress-Induced Reproductive Dysfunction
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Published in |
Frontiers in endocrinology, April 2017
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DOI | 10.3389/fendo.2017.00062 |
Pubmed ID | |
Authors |
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Minoru Irahara |
Abstract |
Physical and psychological stressors suppress hypothalamic-pituitary-gonadal axis activity and sexual behavior and consequently induce reproductive dysfunction. Recently, it has been shown that gonadotropin-inhibitory hormone (GnIH), also called RFamide-related peptide 3 (RFRP) in mammals, which is a potent inhibitory regulator of gonadotropin-releasing hormone (GnRH) and gonadotropin, is involved in stress-induced reproductive dysfunction. GnIH/Rfrp (the gene coding RFRP-3) expression and activity are increased by psychological and immune stress, and this alteration suppresses GnRH and gonadotropin secretion. Glucocorticoid acts as a mediator that interacts between stress and hypothalamic GnIH/RFRP-3. GnIH/RFRP-3 also plays important roles in stress-induced suppression of sexual behavior and infertility, and genetic silencing of GnIH/Rfrp completely recovers sexual behavior and fertility. This review summarizes what is currently known about the roles of GnIH in stress-induced reproductive dysfunction. |
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Switzerland | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 19% |
Student > Ph. D. Student | 7 | 15% |
Student > Postgraduate | 5 | 11% |
Researcher | 4 | 9% |
Student > Bachelor | 3 | 6% |
Other | 7 | 15% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
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Neuroscience | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Agricultural and Biological Sciences | 3 | 6% |
Psychology | 2 | 4% |
Other | 8 | 17% |
Unknown | 14 | 30% |