Title |
Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling
|
---|---|
Published in |
Frontiers in endocrinology, May 2017
|
DOI | 10.3389/fendo.2017.00087 |
Pubmed ID | |
Authors |
Lewan Parker, Christopher S. Shaw, Nigel K. Stepto, Itamar Levinger |
Abstract |
Physical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK) and mitogen-activated protein kinase signaling pathways. Sustained SAPK activation leads to aberrant insulin signaling, impaired glycemic control, and the development and progression of cardiometabolic disease. Paradoxically, acute exercise transiently increases oxidative stress and SAPK signaling, yet postexercise glycemic control and skeletal muscle function are enhanced. Furthermore, regular exercise leads to the upregulation of antioxidant defense, which likely assists in the mitigation of chronic oxidative stress-associated disease. In this review, we explore the complex spatiotemporal interplay between exercise, oxidative stress, and glycemic control, and highlight exercise-induced reactive oxygen species and redox-sensitive protein signaling as important regulators of glucose homeostasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 19% |
Australia | 3 | 14% |
Greece | 2 | 10% |
Taiwan | 1 | 5% |
South Africa | 1 | 5% |
Chile | 1 | 5% |
Slovenia | 1 | 5% |
India | 1 | 5% |
United States | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 24% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 52% |
Scientists | 8 | 38% |
Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 18% |
Student > Master | 9 | 12% |
Student > Ph. D. Student | 8 | 11% |
Student > Doctoral Student | 5 | 7% |
Other | 4 | 5% |
Other | 15 | 20% |
Unknown | 21 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 21% |
Sports and Recreations | 12 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Agricultural and Biological Sciences | 5 | 7% |
Nursing and Health Professions | 4 | 5% |
Other | 7 | 9% |
Unknown | 26 | 34% |