Title |
Host–Microbiota Mutualism in Metabolic Diseases
|
---|---|
Published in |
Frontiers in endocrinology, October 2017
|
DOI | 10.3389/fendo.2017.00267 |
Pubmed ID | |
Authors |
Salvatore Fabbiano, Nicolas Suárez-Zamorano, Mirko Trajkovski |
Abstract |
The intestinal microbiota is a plastic ecosystem that is shaped by environmental and genetic factors, interacting with virtually all tissues of the host. Many signals result from the interplay between the microbiota with its mammalian symbiont that can lead to altered metabolism. Disruptions in the microbial composition are associated with a number of comorbidities linked to the metabolic syndrome. Promoting the niche expansion of beneficial bacteria through diet and supplements can improve metabolic disorders. Reintroducing bacteria through probiotic treatment or fecal transplant is a strategy under active investigation for multiple pathological conditions. Here, we review the recent knowledge of microbiota's contribution to host pathology, the modulation of the microbiota by dietary habits, and the potential therapeutic benefits of reshaping the gut bacterial landscape in context of metabolic disorders such as obesity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 17% |
Brazil | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 105 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 14% |
Student > Ph. D. Student | 14 | 13% |
Student > Bachelor | 12 | 11% |
Student > Master | 12 | 11% |
Professor | 5 | 5% |
Other | 17 | 16% |
Unknown | 30 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 19 | 18% |
Medicine and Dentistry | 17 | 16% |
Immunology and Microbiology | 11 | 10% |
Agricultural and Biological Sciences | 10 | 10% |
Chemistry | 3 | 3% |
Other | 11 | 10% |
Unknown | 34 | 32% |