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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond
|
|---|---|
| Published in |
Frontiers in endocrinology, November 2017
|
| DOI | 10.3389/fendo.2017.00307 |
| Pubmed ID | |
| Authors |
Kate L. Loveland, Britta Klein, Dana Pueschl, Sivanjah Indumathy, Martin Bergmann, Bruce E. Loveland, Mark P. Hedger, Hans-Christian Schuppe |
| Abstract |
Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to restoring, preserving or restricting fertility in humans. This review discusses the growing understanding of how cytokines contribute to testicular function and maintenance of male reproductive health, and to the pathologies associated with their abnormal activity in this organ. Here we consider both cytokines that signal through JAKs and are regulated by SOCS, and those utilizing other pathways, such as the MAP kinases and SMADs. The importance of cytokines in the establishment and maintenance of the testis as an immune-privilege site are described. Current research relating to the involvement of immune cells in testis development and disease is highlighted. This includes new data relating to testicular cancer which reinforce the understanding that tumorigenic cells shape their microenvironment through cytokine actions. Clinical implications in pathologies relating to local inflammation and to immunotherapies are discussed. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 164 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 12% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 18 | 11% |
| Student > Ph. D. Student | 17 | 10% |
| Student > Doctoral Student | 11 | 7% |
| Other | 26 | 16% |
| Unknown | 52 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 18% |
| Medicine and Dentistry | 27 | 16% |
| Agricultural and Biological Sciences | 12 | 7% |
| Immunology and Microbiology | 9 | 5% |
| Veterinary Science and Veterinary Medicine | 6 | 4% |
| Other | 21 | 13% |
| Unknown | 59 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2021.
All research outputs
#15,173,117
of 25,382,440 outputs
Outputs from Frontiers in endocrinology
#3,366
of 13,021 outputs
Outputs of similar age
#230,754
of 445,134 outputs
Outputs of similar age from Frontiers in endocrinology
#33
of 99 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,021 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,134 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.