Title |
Kisspeptin/Kisspeptin Receptor System in the Ovary
|
---|---|
Published in |
Frontiers in endocrinology, January 2018
|
DOI | 10.3389/fendo.2017.00365 |
Pubmed ID | |
Authors |
Kai-Lun Hu, Hongcui Zhao, Hsun-Ming Chang, Yang Yu, Jie Qiao |
Abstract |
Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic-pituitary-gonadal axis. Recent studies have shown that kisspeptin and its receptor kisspeptin receptor (KISS1R) are expressed in the mammalian ovary. Convincing evidence indicates that kisspeptins can activate a wide variety of signals via its binding to KISS1R. Experimental data gathered recently suggest a putative role of kisspeptin signaling in the direct control of ovarian function, including follicular development, oocyte maturation, steroidogenesis, and ovulation. Dysregulation or naturally occurring mutations of the kisspeptin/KISS1R system may negatively affect the ovarian function, leading to reproductive pathology or female infertility. A comprehensive understanding of the expression, actions, and underlying molecular mechanisms of this system in the human ovary is essential for novel approaches to therapeutic and diagnostic interventions in reproductive diseases and infertility. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 2 | 8% |
Switzerland | 2 | 8% |
Nigeria | 1 | 4% |
Honduras | 1 | 4% |
Chile | 1 | 4% |
United States | 1 | 4% |
Angola | 1 | 4% |
Peru | 1 | 4% |
Venezuela, Bolivarian Republic of | 1 | 4% |
Other | 4 | 16% |
Unknown | 10 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 19 | 76% |
Scientists | 5 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 115 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 11% |
Student > Bachelor | 13 | 11% |
Researcher | 12 | 10% |
Student > Ph. D. Student | 10 | 9% |
Student > Postgraduate | 5 | 4% |
Other | 10 | 9% |
Unknown | 52 | 45% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 13 | 11% |
Agricultural and Biological Sciences | 10 | 9% |
Veterinary Science and Veterinary Medicine | 8 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 9 | 8% |
Unknown | 54 | 47% |