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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects
|
|---|---|
| Published in |
Frontiers in endocrinology, February 2018
|
| DOI | 10.3389/fendo.2018.00035 |
| Pubmed ID | |
| Authors |
Farhad Dehkhoda, Christine M. M. Lee, Johan Medina, Andrew J. Brooks |
| Abstract |
The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems. In addition, growth hormone signaling is an important regulator of aging and plays a significant role in cancer development. Growth hormone activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor. JAK2 activation is required for growth hormone-mediated activation of STAT1, STAT3, and STAT5, and the negative regulation of JAK-STAT signaling comprises an important step in the control of this signaling pathway. The GHR also activates the Src family kinase signaling pathway independent of JAK2. This review covers the molecular mechanisms of GHR activation and signal transduction as well as the physiological consequences of growth hormone signaling. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 40% |
| New Zealand | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 390 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 390 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 54 | 14% |
| Student > Ph. D. Student | 45 | 12% |
| Student > Master | 39 | 10% |
| Researcher | 37 | 9% |
| Student > Doctoral Student | 18 | 5% |
| Other | 44 | 11% |
| Unknown | 153 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 77 | 20% |
| Medicine and Dentistry | 47 | 12% |
| Agricultural and Biological Sciences | 31 | 8% |
| Neuroscience | 12 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 53 | 14% |
| Unknown | 160 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2021.
All research outputs
#2,313,335
of 25,508,813 outputs
Outputs from Frontiers in endocrinology
#618
of 13,156 outputs
Outputs of similar age
#54,057
of 456,000 outputs
Outputs of similar age from Frontiers in endocrinology
#9
of 144 outputs
Altmetric has tracked 25,508,813 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,156 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 456,000 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.