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Peculiarities of Precocious Puberty in Boys and Girls With McCune-Albright Syndrome

Overview of attention for article published in Frontiers in endocrinology, June 2018
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Title
Peculiarities of Precocious Puberty in Boys and Girls With McCune-Albright Syndrome
Published in
Frontiers in endocrinology, June 2018
DOI 10.3389/fendo.2018.00337
Pubmed ID
Authors

Domenico Corica, Tommaso Aversa, Giorgia Pepe, Filippo De Luca, Malgorzata Wasniewska

Abstract

McCune-Albright Syndrome (MAS; OMIM # 174800) is a rare, sporadic disease caused by a post-zygotic, activating mutation in the guanine-nucleotide binding protein α-subunit (GNAS1) gene. MAS is characterized by the clinical triad of polyostotic fibrous dysplasia of bone, café-au-lait skin pigmentation and peripheral precocious puberty. However, clinical presentation is highly variable depending on mosaic tissue distribution of mutant-bearing cells. Precocious puberty is the most common endocrine manifestation of MAS and is often the presenting, and sometimes the only, clinical sign of MAS. Due to the very low prevalence of MAS, data on course of precocious puberty, effectiveness of treatments and gonadal function during post-pubertal period are lacking. Our knowledge on this issue derives essentially from case reports and small cohorts of patients. The aim of this review is to report all available literature data on clinical aspects, therapeutic management and outcomes of precocious puberty in children with MAS. A systematic research was carried out through MEDLINE via PubMed, EMBASE, Web of Science, Semantic Scholar, Cochrane Library.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 10%
Student > Bachelor 3 10%
Lecturer > Senior Lecturer 2 6%
Student > Postgraduate 2 6%
Professor > Associate Professor 1 3%
Other 1 3%
Unknown 19 61%
Readers by discipline Count As %
Medicine and Dentistry 8 26%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Immunology and Microbiology 1 3%
Nursing and Health Professions 1 3%
Earth and Planetary Sciences 1 3%
Other 1 3%
Unknown 18 58%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2018.
All research outputs
#20,663,600
of 25,385,509 outputs
Outputs from Frontiers in endocrinology
#6,739
of 13,021 outputs
Outputs of similar age
#266,435
of 342,290 outputs
Outputs of similar age from Frontiers in endocrinology
#143
of 209 outputs
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