Title |
Cholesterol: A Gatekeeper of Male Fertility?
|
---|---|
Published in |
Frontiers in endocrinology, July 2018
|
DOI | 10.3389/fendo.2018.00369 |
Pubmed ID | |
Authors |
Lauriane Sèdes, Laura Thirouard, Salwan Maqdasy, Manon Garcia, Françoise Caira, Jean-Marc A. Lobaccaro, Claude Beaudoin, David H. Volle |
Abstract |
Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Male reproductive function has been demonstrated to be dependent on cholesterol homeostasis. Here we review data highlighting the impacts of cholesterol homeostasis on male fertility and the molecular mechanisms implicated through the signaling pathways of some nuclear receptors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 94 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 12% |
Student > Master | 10 | 11% |
Researcher | 10 | 11% |
Student > Bachelor | 8 | 9% |
Other | 7 | 7% |
Other | 10 | 11% |
Unknown | 38 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 16% |
Biochemistry, Genetics and Molecular Biology | 14 | 15% |
Medicine and Dentistry | 13 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Nursing and Health Professions | 3 | 3% |
Other | 7 | 7% |
Unknown | 38 | 40% |