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KISS1/KISS1R in Cancer: Friend or Foe?

Overview of attention for article published in Frontiers in endocrinology, August 2018
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Title
KISS1/KISS1R in Cancer: Friend or Foe?
Published in
Frontiers in endocrinology, August 2018
DOI 10.3389/fendo.2018.00437
Pubmed ID
Authors

Stephania Guzman, Muriel Brackstone, Sally Radovick, Andy V. Babwah, Moshmi M. Bhattacharya

Abstract

The KISS1 gene encodes KISS1, a protein that is rapidly processed in serum into smaller but biologically active peptides called kisspeptins (KPs). KISS1 and the KPs signal via the G-protein coupled receptor KISS1R. While KISS1 and KPs are recognized as potent positive regulators of the reproductive neuroendocrine axis in mammals, the first reported role for KISS1 was that of metastasis suppression in melanoma. Since then, it has become apparent that KISS1, KPs, and KISS1R regulate the development and progression of several cancers but interestingly, while these molecules act as suppressors of tumorigenesis and metastasis in many cancers, in breast and liver cancer they function as promoters. Thus, they join a small but growing number of molecules that exhibit dual roles in cancer highlighting the importance of studying cancer in context. Given their roles, KISS1, KPs and KISS1R represent important molecules in the development of novel therapies and/or as prognostic markers in treating cancer. However, getting to that point requires a detailed understanding of the relationship between these molecules and different cancers. The purpose of this review is therefore to highlight and discuss the clinical studies that have begun describing this relationship in varying cancer types including breast, liver, pancreatic, colorectal, bladder, and ovarian. An emerging theme from the reviewed studies is that the relationship between these molecules and a given cancer is complex and affected by many factors such as the micro-environment and steroid receptor status of the cancer cell. Our review and discussion of these important clinical studies should serve as a valuable resource in the successful development of future clinical studies.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 14%
Researcher 6 12%
Student > Master 5 10%
Student > Ph. D. Student 4 8%
Student > Doctoral Student 3 6%
Other 9 18%
Unknown 16 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 28%
Medicine and Dentistry 12 24%
Agricultural and Biological Sciences 3 6%
Immunology and Microbiology 1 2%
Neuroscience 1 2%
Other 2 4%
Unknown 17 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2020.
All research outputs
#17,242,285
of 25,385,509 outputs
Outputs from Frontiers in endocrinology
#5,130
of 13,021 outputs
Outputs of similar age
#219,364
of 341,622 outputs
Outputs of similar age from Frontiers in endocrinology
#103
of 198 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,021 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,622 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 198 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.