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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The secret language of destiny: stress imprinting and transgenerational origins of disease
|
|---|---|
| Published in |
Frontiers in Genetics, January 2012
|
| DOI | 10.3389/fgene.2012.00096 |
| Pubmed ID | |
| Authors |
Fabiola C. R. Zucchi, Youli Yao, Gerlinde A. Metz |
| Abstract |
Epigenetic regulation modulates gene expression without altering the DNA sequence to facilitate rapid adjustments to dynamically changing environmental conditions. The formation of an epigenetic memory allows passing on this information to subsequent generations. Here we propose that epigenetic memories formed by adverse environmental conditions and stress represent a critical determinant of health and disease in the F3 generation and beyond. Transgenerational programming of epigenetic regulation may represent a key to understand adult-onset complex disease pathogenesis and cumulative effects of life span and familial disease etiology. Ultimately, the mechanisms of generating an epigenetic memory may become of potentially promising diagnostic and therapeutic relevance due to their reversible nature. Exploring the role of environmental factors, such as stress, in causing variations in epigenetic profiles may lead to new avenues of personalized, preventive medicine based on epigenetic signatures and interventions. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 38% |
| United Kingdom | 1 | 13% |
| Chile | 1 | 13% |
| Spain | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Practitioners (doctors, other healthcare professionals) | 2 | 25% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Panama | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Spain | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 111 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 31% |
| Researcher | 18 | 15% |
| Student > Doctoral Student | 10 | 8% |
| Student > Bachelor | 9 | 8% |
| Student > Postgraduate | 6 | 5% |
| Other | 22 | 19% |
| Unknown | 17 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 32% |
| Medicine and Dentistry | 18 | 15% |
| Neuroscience | 13 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Psychology | 8 | 7% |
| Other | 12 | 10% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2018.
All research outputs
#5,417,099
of 22,668,244 outputs
Outputs from Frontiers in Genetics
#1,499
of 11,727 outputs
Outputs of similar age
#48,095
of 244,068 outputs
Outputs of similar age from Frontiers in Genetics
#39
of 255 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,727 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,068 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.