Title |
Evolutionary conservation and functional roles of ncRNA
|
---|---|
Published in |
Frontiers in Genetics, January 2012
|
DOI | 10.3389/fgene.2012.00205 |
Pubmed ID | |
Authors |
Zhipeng Qu, David L. Adelson |
Abstract |
Non-coding RNAs (ncRNAs) are a class of transcribed RNA molecules without protein-coding potential. They were regarded as transcriptional noise, or the byproduct of genetic information flow from DNA to protein for a long time. However, in recent years, a number of studies have shown that ncRNAs are pervasively transcribed, and most of them show evidence of evolutionary conservation, although less conserved than protein-coding genes. More importantly, many ncRNAs have been confirmed as playing crucial regulatory roles in diverse biological processes and tumorigenesis. Here we summarize the functional significance of this class of "dark matter" in terms its genomic organization, evolutionary conservation, and broad functional classes. |
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India | 2 | 33% |
United Kingdom | 1 | 17% |
United States | 1 | 17% |
Switzerland | 1 | 17% |
France | 1 | 17% |
Demographic breakdown
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Members of the public | 4 | 67% |
Scientists | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
United States | 1 | <1% |
Colombia | 1 | <1% |
Unknown | 140 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 31 | 22% |
Student > Master | 23 | 16% |
Student > Bachelor | 21 | 15% |
Researcher | 14 | 10% |
Professor | 8 | 6% |
Other | 22 | 15% |
Unknown | 24 | 17% |
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Agricultural and Biological Sciences | 46 | 32% |
Biochemistry, Genetics and Molecular Biology | 42 | 29% |
Computer Science | 5 | 3% |
Medicine and Dentistry | 4 | 3% |
Chemistry | 4 | 3% |
Other | 14 | 10% |
Unknown | 28 | 20% |