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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19
|
|---|---|
| Published in |
Frontiers in Genetics, January 2012
|
| DOI | 10.3389/fgene.2012.00206 |
| Pubmed ID | |
| Authors |
Nuala Ann Helsby, Kathryn Elisa Burns |
| Abstract |
Inherited variation in the function of the drug metabolizing enzyme CYP2C19 was first observed 40 years ago. The SNP variants which underpin loss of CYP2C19 function have been elucidated and extensively studied in healthy populations. However, there has been relatively meagre translation of this information into the clinic. The presence of genotype-phenotype discordance in certain patients suggests that changes in the regulation of this gene, as well as loss of function SNPs, could play a role in deficient activity of this enzyme. Knowledge of the molecular mechanisms which control transcription of this gene, reviewed in this article, may aid the challenge of delivering CYP2C19 pharmacogenetics into clinical use. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 3% |
| Pakistan | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 37 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 18% |
| Student > Bachelor | 5 | 13% |
| Researcher | 5 | 13% |
| Professor | 5 | 13% |
| Student > Postgraduate | 4 | 10% |
| Other | 9 | 23% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 30% |
| Medicine and Dentistry | 11 | 28% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 15% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Arts and Humanities | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 6 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2012.
All research outputs
#20,169,675
of 22,681,577 outputs
Outputs from Frontiers in Genetics
#8,512
of 11,741 outputs
Outputs of similar age
#221,189
of 244,101 outputs
Outputs of similar age from Frontiers in Genetics
#195
of 255 outputs
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So far Altmetric has tracked 11,741 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.