Title |
Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging
|
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Published in |
Frontiers in Genetics, January 2012
|
DOI | 10.3389/fgene.2012.00218 |
Pubmed ID | |
Authors |
Dae-Eun Jeong, Murat Artan, Keunhee Seo, Seung-Jae Lee |
Abstract |
Many environmental factors that dynamically change in nature influence various aspects of animal physiology. Animals are equipped with sensory neuronal systems that help them properly sense and respond to environmental factors. Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster. Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation. In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Korea, Republic of | 1 | 1% |
China | 1 | 1% |
France | 1 | 1% |
Unknown | 70 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 24% |
Researcher | 11 | 15% |
Student > Master | 11 | 15% |
Student > Bachelor | 8 | 11% |
Student > Doctoral Student | 5 | 7% |
Other | 14 | 19% |
Unknown | 7 | 9% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 21 | 28% |
Neuroscience | 5 | 7% |
Engineering | 2 | 3% |
Immunology and Microbiology | 1 | 1% |
Other | 3 | 4% |
Unknown | 12 | 16% |