Title |
Exploiting Gene Expression Variation to Capture Gene-Environment Interactions for Disease
|
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Published in |
Frontiers in Genetics, January 2013
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DOI | 10.3389/fgene.2012.00228 |
Pubmed ID | |
Authors |
Youssef Idaghdour, Philip Awadalla |
Abstract |
Gene-environment interactions have long been recognized as a fundamental concept in evolutionary, quantitative, and medical genetics. In the genomics era, study of how environment and genome interact to shape gene expression variation is relevant to understanding the genetic architecture of complex phenotypes. While genetic analysis of gene expression variation focused on main effects, little is known about the extent of interaction effects implicating regulatory variants and their consequences on transcriptional variation. Here we survey the current state of the concept of transcriptional gene-environment interactions and discuss its utility for mapping disease phenotypes in light of the insights gained from genome-wide association studies of gene expression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 30% |
Researcher | 10 | 22% |
Professor > Associate Professor | 5 | 11% |
Student > Doctoral Student | 3 | 7% |
Student > Master | 2 | 4% |
Other | 5 | 11% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 37% |
Medicine and Dentistry | 7 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Computer Science | 2 | 4% |
Neuroscience | 2 | 4% |
Other | 2 | 4% |
Unknown | 10 | 22% |