Title |
The household contact study design for genetic epidemiological studies of infectious diseases
|
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Published in |
Frontiers in Genetics, January 2013
|
DOI | 10.3389/fgene.2013.00061 |
Pubmed ID | |
Authors |
Catherine M. Stein, Noémi B. Hall, LaShaunda L. Malone, Ezekiel Mupere |
Abstract |
MOST GENETIC EPIDEMIOLOGICAL STUDY DESIGNS FALL INTO ONE OF TWO CATEGORIES: family based and population-based (case-control). However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 30% |
Researcher | 5 | 15% |
Student > Ph. D. Student | 4 | 12% |
Unspecified | 2 | 6% |
Professor | 2 | 6% |
Other | 5 | 15% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 33% |
Agricultural and Biological Sciences | 5 | 15% |
Nursing and Health Professions | 3 | 9% |
Immunology and Microbiology | 2 | 6% |
Unspecified | 2 | 6% |
Other | 4 | 12% |
Unknown | 6 | 18% |