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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-Wide Association Study of Personality Traits in the Long Life Family Study
|
|---|---|
| Published in |
Frontiers in Genetics, January 2013
|
| DOI | 10.3389/fgene.2013.00065 |
| Pubmed ID | |
| Authors |
Harold T. Bae, Paola Sebastiani, Jenny X. Sun, Stacy L. Andersen, E. Warwick Daw, Antonio Terracciano, Luigi Ferrucci, Thomas T. Perls |
| Abstract |
Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p < 10(-8)) and replicated in an additional sample of 1279 LLFS subjects, although one (rs9650241) failed to replicate and the other two were not available in two independent replication cohorts, the Baltimore Longitudinal Study of Aging and the New England Centenarian Study. Based on 10,000,000 permutations, the empirical p-value of 2 × 10(-7) was observed for the genome-wide significant SNPs. Seventeen SNPs that reached marginal statistical significance in the two previous GWASs (p-value <10(-4) and 10(-5)), were also marginally significantly associated in this study (p-value <0.05), although none of the associations passed the Bonferroni correction. In addition, we tested age-by-SNP interactions and found some significant associations. Since scores of personality traits in LLFS subjects change in the oldest ages, and genetic factors outweigh environmental factors to achieve extreme ages, these age-by-SNP interactions could be a proxy for complex gene-gene interactions affecting personality traits and longevity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 15% |
| Student > Master | 7 | 15% |
| Student > Ph. D. Student | 6 | 13% |
| Student > Bachelor | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Other | 6 | 13% |
| Unknown | 12 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 23% |
| Agricultural and Biological Sciences | 6 | 13% |
| Medicine and Dentistry | 6 | 13% |
| Social Sciences | 3 | 6% |
| Neuroscience | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 15 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2014.
All research outputs
#15,271,180
of 22,709,015 outputs
Outputs from Frontiers in Genetics
#5,392
of 11,756 outputs
Outputs of similar age
#181,489
of 280,729 outputs
Outputs of similar age from Frontiers in Genetics
#205
of 319 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,756 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,729 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 319 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.