Title |
A review of potassium channels in bipolar disorder
|
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Published in |
Frontiers in Genetics, January 2013
|
DOI | 10.3389/fgene.2013.00105 |
Pubmed ID | |
Authors |
Jennifer T. Judy, Peter P. Zandi |
Abstract |
Although bipolar disorder (BP) is one of the most heritable psychiatric conditions, susceptibility genes for the disorder have yet to be conclusively identified. It is likely that variants in multiple genes across multiple pathways contribute to the genotype-phenotype relationship in the affected population. Recent evidence from genome-wide association studies implicates an entire class of genes related to the structure and regulation of ion channels, suggesting that the etiology of BP may arise from channelopathies. In this review, we examine the evidence for this hypothesis, with a focus on the potential role of voltage-gated potassium channels. We consider evidence from genetic and expression studies, and discuss the potential underlying biology. We consider animal models and treatment implications of the involvement of potassium ion channelopathy in BP. Finally, we explore intriguing parallels between BP and epilepsy, the signature channelopathy of the central nervous system. |
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Turkey | 2 | 25% |
Greece | 1 | 13% |
Australia | 1 | 13% |
Ireland | 1 | 13% |
Switzerland | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 75% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
Geographical breakdown
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Germany | 2 | 3% |
Chile | 1 | 1% |
Unknown | 69 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 19% |
Student > Bachelor | 12 | 17% |
Student > Ph. D. Student | 9 | 13% |
Professor > Associate Professor | 8 | 11% |
Other | 5 | 7% |
Other | 12 | 17% |
Unknown | 12 | 17% |
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Medicine and Dentistry | 10 | 14% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Neuroscience | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Other | 9 | 13% |
Unknown | 15 | 21% |