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Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin?

Overview of attention for article published in Frontiers in Genetics, January 2013
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Title
Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin?
Published in
Frontiers in Genetics, January 2013
DOI 10.3389/fgene.2013.00139
Pubmed ID
Authors

Velibor Savic

Abstract

In the last decade, a lot has been done in elucidating the sequence of events that occur at the nascent double strand DNA break. Nevertheless, the overall structure formed by the DNA damage response (DDR) factors around the break site, the repair focus, remains poorly understood. Although most of the data presented so far only address events that occur in chromatin in cis around the break, there are strong indications that in mammalian systems it may also occur in trans, analogous to the recent findings showing this if budding yeast. There have been attempts to address the issue but the final proof is still missing due to lack of a proper experimental system. If found to be true, the spatial distribution of DDR factors would have a major impact on the neighboring chromatin both in cis and in trans, significantly affecting local chromatin function; gene transcription and potentially other functions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
United States 1 4%
India 1 4%
Unknown 21 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 33%
Researcher 8 33%
Professor > Associate Professor 5 21%
Student > Master 2 8%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 63%
Biochemistry, Genetics and Molecular Biology 6 25%
Physics and Astronomy 1 4%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2013.
All research outputs
#18,341,711
of 22,714,025 outputs
Outputs from Frontiers in Genetics
#6,995
of 11,756 outputs
Outputs of similar age
#218,044
of 280,752 outputs
Outputs of similar age from Frontiers in Genetics
#236
of 319 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,756 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
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