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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A CRISPR CASe for high-throughput silencing
|
|---|---|
| Published in |
Frontiers in Genetics, January 2013
|
| DOI | 10.3389/fgene.2013.00193 |
| Pubmed ID | |
| Authors |
Jacob Heintze, Christin Luft, Robin Ketteler |
| Abstract |
Manipulation of gene expression on a genome-wide level is one of the most important systematic tools in the post-genome era. Such manipulations have largely been enabled by expression cloning approaches using sequence-verified cDNA libraries, large-scale RNA interference libraries (shRNA or siRNA) and zinc finger nuclease technologies. More recently, the CRISPR (clustered regularly interspaced short palindromic repeats) and CRISPR-associated (Cas)9-mediated gene editing technology has been described that holds great promise for future use of this technology in genomic manipulation. It was suggested that the CRISPR system has the potential to be used in high-throughput, large-scale loss of function screening. Here we discuss some of the challenges in engineering of CRISPR/Cas genomic libraries and some of the aspects that need to be addressed in order to use this technology on a high-throughput scale. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| Germany | 1 | 25% |
| India | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 336 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Germany | 3 | <1% |
| United Kingdom | 3 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Switzerland | 1 | <1% |
| Cuba | 1 | <1% |
| Hong Kong | 1 | <1% |
| Australia | 1 | <1% |
| Other | 5 | 1% |
| Unknown | 313 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 85 | 25% |
| Student > Ph. D. Student | 72 | 21% |
| Student > Master | 39 | 12% |
| Student > Bachelor | 36 | 11% |
| Student > Doctoral Student | 18 | 5% |
| Other | 47 | 14% |
| Unknown | 39 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 179 | 53% |
| Biochemistry, Genetics and Molecular Biology | 64 | 19% |
| Medicine and Dentistry | 19 | 6% |
| Immunology and Microbiology | 6 | 2% |
| Neuroscience | 4 | 1% |
| Other | 16 | 5% |
| Unknown | 48 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2022.
All research outputs
#2,130,007
of 22,880,230 outputs
Outputs from Frontiers in Genetics
#501
of 11,919 outputs
Outputs of similar age
#22,071
of 281,332 outputs
Outputs of similar age from Frontiers in Genetics
#27
of 319 outputs
Altmetric has tracked 22,880,230 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,919 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,332 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 319 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.