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Mendeley readers
Attention Score in Context
| Title |
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
|
|---|---|
| Published in |
Frontiers in Genetics, January 2013
|
| DOI | 10.3389/fgene.2013.00256 |
| Pubmed ID | |
| Authors |
Angela M. Arensdorf, Danilo Diedrichs, D. Thomas Rutkowski |
| Abstract |
The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally characterized as a pathway for upregulating ER chaperones, and a comprehensive body of subsequent work has shown that protein synthesis, folding, oxidation, trafficking, and degradation are all transcriptionally enhanced by the UPR. However, the global reach of the UPR extends to genes involved in diverse physiological processes having seemingly little to do with ER protein folding, and this includes a substantial number of mRNAs that are suppressed by stress rather than stimulated. Through multiple non-canonical mechanisms emanating from each of the UPR pathways, the cell dynamically regulates transcription and mRNA degradation. Here we highlight these mechanisms and their increasingly appreciated impact on physiological processes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Ireland | 1 | <1% |
| Mexico | 1 | <1% |
| Czechia | 1 | <1% |
| Unknown | 122 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 31% |
| Researcher | 23 | 18% |
| Student > Master | 13 | 10% |
| Student > Bachelor | 9 | 7% |
| Professor > Associate Professor | 9 | 7% |
| Other | 18 | 14% |
| Unknown | 17 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 35% |
| Biochemistry, Genetics and Molecular Biology | 33 | 26% |
| Medicine and Dentistry | 8 | 6% |
| Neuroscience | 6 | 5% |
| Chemistry | 5 | 4% |
| Other | 11 | 9% |
| Unknown | 21 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2013.
All research outputs
#15,235,403
of 22,733,113 outputs
Outputs from Frontiers in Genetics
#5,326
of 11,757 outputs
Outputs of similar age
#180,939
of 280,780 outputs
Outputs of similar age from Frontiers in Genetics
#200
of 319 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,757 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,780 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 319 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.