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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The anti-miR21 antagomir, a therapeutic tool for colorectal cancer, has a potential synergistic effect by perturbing an angiogenesis-associated miR30
|
|---|---|
| Published in |
Frontiers in Genetics, January 2014
|
| DOI | 10.3389/fgene.2013.00301 |
| Pubmed ID | |
| Authors |
Min-Sun Song, John J. Rossi |
| Abstract |
Colon cancer has the third highest incidence and mortality among cancers in the United States. MicroRNA-21 (miR21) has been described as an oncomir that is highly overexpressed in tumor tissue from colorectal cancer. Recent studies showed that silencing of miR21 through use of a miR21 inhibitor (anti-miR21) affected viability, apoptosis and the cell cycle in colon cancer cells. We identified an anti-miR21 that targets miR21 to inhibit genes by both post-transcriptional gene silencing and transcriptional gene silencing in the cytoplasm and nucleus, respectively. Overexpression of anti-miR21 in colon cancer cells caused changes in miRNA expression levels. We found that treatment with anti-miR21 down-regulated expression of miR30, which is involved in angiogenesis. In an in vitro angiogenesis assay, network formation induced by an angiogenesis activator was reduced upon treatment with anti-miR21. Sequence analysis of anti-miR21 and pri-miR30 revealed homology between anti-miR21 and the 3' end of pri-miR30, suggesting that anti-miR21 may bind to pri-miR30 and block processing of the miRNA processing. These results suggest anti-miR21 has a role not only in tumor growth but also in angiogenesis. Therefore, treatment with the anti-miR21 antagomir may have a synergistic effect mediated through suppression of miR30. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 22% |
| Researcher | 8 | 16% |
| Student > Master | 7 | 14% |
| Student > Bachelor | 6 | 12% |
| Student > Doctoral Student | 3 | 6% |
| Other | 2 | 4% |
| Unknown | 13 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 20% |
| Biochemistry, Genetics and Molecular Biology | 10 | 20% |
| Medicine and Dentistry | 7 | 14% |
| Chemistry | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 14 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2014.
All research outputs
#14,186,260
of 22,738,543 outputs
Outputs from Frontiers in Genetics
#3,906
of 11,757 outputs
Outputs of similar age
#173,612
of 305,211 outputs
Outputs of similar age from Frontiers in Genetics
#32
of 54 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,757 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,211 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.