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Bacterial SET domain proteins and their role in eukaryotic chromatin modification

Overview of attention for article published in Frontiers in Genetics, April 2014
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Title
Bacterial SET domain proteins and their role in eukaryotic chromatin modification
Published in
Frontiers in Genetics, April 2014
DOI 10.3389/fgene.2014.00065
Pubmed ID
Authors

Raúl Alvarez-Venegas

Abstract

It has been shown by many researchers that SET-domain containing proteins modify chromatin structure and, as expected, genes coding for SET-domain containing proteins have been found in all eukaryotic genomes sequenced to date. However, during the last years, a great number of bacterial genomes have been sequenced and an important number of putative genes involved in histone post-translational modifications (histone PTMs) have been identified in many bacterial genomes. Here, I aim at presenting an overview of SET domain genes that have been identified in numbers of bacterial genomes based on similarity to SET domains of eukaryotic histone methyltransferases. I will argue in favor of the hypothesis that SET domain genes found in extant bacteria are of bacterial origin. Then, I will focus on the available information on pathogen and symbiont SET-domain containing proteins and their targets in eukaryotic organisms, and how such histone methyltransferases allow a pathogen to inhibit transcriptional activation of host defense genes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 23%
Researcher 11 17%
Student > Bachelor 8 12%
Student > Master 7 11%
Student > Doctoral Student 5 8%
Other 11 17%
Unknown 9 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 47%
Biochemistry, Genetics and Molecular Biology 19 29%
Chemistry 2 3%
Immunology and Microbiology 2 3%
Unspecified 1 2%
Other 0 0%
Unknown 11 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2014.
All research outputs
#20,226,756
of 22,751,628 outputs
Outputs from Frontiers in Genetics
#8,553
of 11,758 outputs
Outputs of similar age
#192,734
of 225,531 outputs
Outputs of similar age from Frontiers in Genetics
#73
of 82 outputs
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