Title |
Trans-regulation of RNA-binding protein motifs by microRNA
|
---|---|
Published in |
Frontiers in Genetics, April 2014
|
DOI | 10.3389/fgene.2014.00079 |
Pubmed ID | |
Authors |
Francis Doyle, Scott A. Tenenbaum |
Abstract |
The wide array of vital functions that RNA performs is dependent on its ability to dynamically fold into different structures in response to intracellular and extracellular changes. RNA-binding proteins regulate much of this activity by targeting specific RNA structures or motifs. One of these structures, the 3-way RNA junction, is characteristically found in ribosomal RNA and results from the RNA folding in cis, to produce three separate helices that meet around a central unpaired region. Here we demonstrate that 3-way junctions can also form in trans as a result of the binding of microRNAs in an unconventional manner with mRNA by splinting two non-contiguous regions together. This may be used to reinforce the base of a stem-loop motif being targeted by an RNA-binding protein. Trans interactions between non-coding RNA and mRNA may be used to control the post-transcriptional regulatory code and suggests a possible role for some of the recently described transcripts of unknown function expressed from the human genome. |
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France | 2 | 25% |
India | 1 | 13% |
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Demographic breakdown
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Scientists | 2 | 25% |
Mendeley readers
Geographical breakdown
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Turkey | 1 | 2% |
Austria | 1 | 2% |
Brazil | 1 | 2% |
Sweden | 1 | 2% |
United Kingdom | 1 | 2% |
Denmark | 1 | 2% |
United States | 1 | 2% |
Unknown | 58 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 22% |
Student > Ph. D. Student | 13 | 20% |
Student > Master | 7 | 11% |
Professor | 5 | 8% |
Student > Doctoral Student | 5 | 8% |
Other | 11 | 17% |
Unknown | 10 | 15% |
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Biochemistry, Genetics and Molecular Biology | 15 | 23% |
Neuroscience | 2 | 3% |
Engineering | 2 | 3% |
Chemistry | 2 | 3% |
Other | 5 | 8% |
Unknown | 14 | 22% |