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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation
|
|---|---|
| Published in |
Frontiers in Genetics, May 2014
|
| DOI | 10.3389/fgene.2014.00135 |
| Pubmed ID | |
| Authors |
Toshifumi Inada, Shiho Makino |
| Abstract |
The CCR4-NOT complex is a highly conserved specific gene silencer that also serves more general post-transcriptional functions. Specific regulatory proteins including the miRNA-induced silencing complex and its associated proteins, bind to 3'-UTR elements of mRNA and recruit the CCR4-NOT complex thereby promoting poly(A) shortening and repressing translation and/or mRNA degradation. Recent studies have shown that the CCR4-NOT complex that is tethered to mRNA by such regulator(s) represses translation and facilitates mRNA decay independent of a poly(A) tail and its shortening. In addition to deadenylase activity, the CCR4-NOT complex also has an E3 ubiquitin ligase activity and is involved in a novel protein quality control system, i.e., co-translational proteasomal-degradation of aberrant proteins. In this review, we describe recent progress in elucidation of novel roles of the multi-functional complex CCR4-NOT in post-transcriptional regulation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 2 | 2% |
| Germany | 2 | 2% |
| Switzerland | 1 | <1% |
| Unknown | 125 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 32% |
| Student > Master | 21 | 16% |
| Researcher | 17 | 13% |
| Student > Bachelor | 10 | 8% |
| Professor | 6 | 5% |
| Other | 17 | 13% |
| Unknown | 18 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 49 | 38% |
| Biochemistry, Genetics and Molecular Biology | 48 | 37% |
| Unspecified | 4 | 3% |
| Immunology and Microbiology | 3 | 2% |
| Chemistry | 2 | 2% |
| Other | 4 | 3% |
| Unknown | 20 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2014.
All research outputs
#14,196,440
of 22,756,196 outputs
Outputs from Frontiers in Genetics
#3,912
of 11,758 outputs
Outputs of similar age
#119,188
of 226,286 outputs
Outputs of similar age from Frontiers in Genetics
#73
of 115 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,758 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,286 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.